Description

1-(Phenylsulphonyl)-4-Fluoro-2-Iodo-7-Azaindole is a high-purity, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for medicinal chemistry research and development, serving as a key intermediate in the synthesis of novel pharmaceutical candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate complex halogenated and sulfonylated azaindole motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A versatile scaffold for the synthesis of kinase inhibitors and other small-molecule therapeutics targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its reactive halogen and sulfonyl functional groups.
• Agrochemical Development: Serves as a building block for creating novel active ingredients with potential herbicidal or insecticidal properties.
• Chemical Biology Probes: Useful for the development of molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-(Phenylsulphonyl)-4-Fluoro-2-Iodo-7-Azaindole
CAS No.	1227270-45-2
Molecular Formula	C₁₃H₈FIN₂O₂S
Molecular Weight	402.18 g/mol
Synonyms	1-(Benzenesulfonyl)-4-fluoro-2-iodo-1H-pyrrolo[2,3-b]pyridine; 4-Fluoro-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-fluoro-2-iodo-1-(phenylsulfonyl)-; 4-Fluoro-2-iodo-7-azaindole-1-sulfonic acid phenyl ester; 7-Azaindole, 1-(phenylsulfonyl)-4-fluoro-2-iodo-; CAS 1227270-45-2
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-4-Fluoro-2-Iodo-7-Azaindole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be aligned with client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.