Description

1-(Phenylsulphonyl)-6-Bromo-5-Methoxy-7-Azaindole is a high-purity, advanced pharmaceutical intermediate characterized by its unique azaindole core functionalized with bromo and methoxy groups. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing kinase inhibitors and other small molecule drugs targeting oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of targeted small molecule drugs, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its versatile chemical handle.
• API Development: Serves as a precursor in the development of Active Pharmaceutical Ingredients (APIs) for clinical trials.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme function and cellular signaling pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for pharmaceutical clients.

Basic Information

Product Name	1-(Phenylsulphonyl)-6-Bromo-5-Methoxy-7-Azaindole
CAS No.	1227270-28-1
Molecular Formula	C₁₈H₁₄BrN₃O₃S
Molecular Weight	432.29 g/mol
Synonyms	6-Bromo-5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 6-Bromo-5-methoxy-1-(phenylsulfonyl)-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 6-bromo-5-methoxy-1-(phenylsulfonyl)-; 1-(Phenylsulfonyl)-6-bromo-5-methoxy-1H-pyrrolo[2,3-b]pyridine; 6-Bromo-5-methoxy-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-6-Bromo-5-Methoxy-7-Azaindole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring material traceability and reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.