Description

1-(Phenylsulphonyl)-6-Cyano-4-Chloro-7-Azaindole is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring a 7-azaindole core with strategically positioned sulfonyl, cyano, and chloro substituents, makes it a versatile and valuable intermediate for constructing complex pharmacophores. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents, leveraging the 7-azaindole scaffold's bioactivity.
• Agrochemical Research: Used in the development of new herbicides and fungicides, where the chloro and cyano groups contribute to biological activity.
• Material Science: Serves as a building block for advanced organic electronic materials and functional dyes due to its electron-deficient aromatic system.
• Chemical Biology: Employed as a probe or linker in the design of chemical tools for studying biological pathways and protein interactions.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring complex heterocyclic chemistry.

Basic Information

Product Name	1-(Phenylsulphonyl)-6-Cyano-4-Chloro-7-Azaindole
CAS No.	1227270-27-0
Molecular Formula	C14H8ClN3O2S
Molecular Weight	317.75 g/mol
Synonyms	4-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-6-carbonitrile; 4-Chloro-1-(phenylsulfonyl)-6-cyano-7-azaindole; 6-Cyano-4-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-6-carbonitrile, 4-chloro-1-(phenylsulfonyl)-; 1-(Phenylsulfonyl)-4-chloro-6-cyano-7-azaindole; 1-(Benzenesulfonyl)-4-chloro-6-cyano-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-6-Cyano-4-Chloro-7-Azaindole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.