Description

2-Iodo-6-Azaindole is a high-value halogenated heterocyclic building block, specifically designed for advanced pharmaceutical and agrochemical research. This compound is critical for medicinal chemists seeking to introduce iodine atoms into complex molecular architectures, enabling key reactions like cross-coupling and facilitating structure-activity relationship (SAR) studies. It is primarily utilized by R&D departments in pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the 6-azaindole scaffold offers unique biological activity.
• Material Science: Acts as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings to create complex biaryl structures.
• Chemical Biology & Proteomics: Employed as a molecular probe or tag due to the reactivity of the iodine handle for bioconjugation.
• Academic & Discovery Chemistry: A valuable reagent for exploring new synthetic methodologies and constructing diverse heterocyclic libraries for screening.

Basic Information

Product Name	2-Iodo-6-Azaindole
CAS No.	1227270-26-9
Molecular Formula	C7H5IN2
Molecular Weight	244.03 g/mol
Synonyms	2-Iodo-1H-pyrrolo[2,3-b]pyridine; 6-Azaindole, 2-iodo-; 1H-Pyrrolo[2,3-b]pyridine, 2-iodo-; 2-Iodo-1H-pyrrolo[2,3-b]pyridine; 2-Iodopyrrolo[2,3-b]pyridine; 2-Iodo-7-azaindole (common misnomer); 2-Iodo-6-aza-indole
EINECS	Contact for details

Quality Control

Our 2-Iodo-6-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.