Description

1-(Phenylsulfonyl)-2-Iodo-7-Azaindole-5-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and sulfonylated azaindole scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel, targeted small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the discovery of kinase inhibitors and other biologically active heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and library synthesis due to its reactive aldehyde and halogen functional groups.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and cellular signaling pathways.
• Organic Synthesis Reagent: Serves as a specialized substrate in palladium-catalyzed cross-coupling reactions, such as Suzuki or Sonogashira couplings.
• API Development: Used in the research and early-stage development of new Active Pharmaceutical Ingredients (APIs) with potential therapeutic applications.

Basic Information

Product Name	1-(Phenylsulfonyl)-2-Iodo-7-Azaindole-5-Carbaldehyde
CAS No.	1227270-23-6
Molecular Formula	C₁₄H₉IN₂O₃S
Molecular Weight	412.20 g/mol
Synonyms	2-Iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde; 1H-Pyrrolo[2,3-b]pyridine-5-carbaldehyde, 2-iodo-1-(phenylsulfonyl)-; 2-Iodo-7-azaindole-5-carbaldehyde 1-phenylsulfonyl derivative; 1-Benzenesulfonyl-2-iodo-7-azaindole-5-carboxaldehyde
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulfonyl)-2-Iodo-7-Azaindole-5-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation. Keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.