Description

1-(Phenylsulphonyl)-6-Fluoro-2-Iodo-7-Azaindole is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of targeted pharmaceutical agents, particularly kinase inhibitors, due to its unique halogenated and sulfonylated azaindole scaffold. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for lead optimization and the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of small molecule kinase inhibitors and other targeted therapeutics.
• Medicinal Chemistry Research: Used in lead compound optimization and structure-activity relationship (SAR) studies due to its modifiable functional groups.
• Agrochemical Development: Serves as a precursor in the research and synthesis of novel herbicides or fungicides.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and cellular pathways.
• Organic Synthesis: Acts as a versatile substrate for cross-coupling reactions (e.g., Suzuki, Sonogashira) and further functionalization.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development programs.

Basic Information

Product Name	1-(Phenylsulphonyl)-6-Fluoro-2-Iodo-7-Azaindole
CAS No.	1227270-19-0
Molecular Formula	C₁₃H₈FIN₂O₂S
Molecular Weight	402.18 g/mol
Synonyms	1-(Phenylsulfonyl)-6-fluoro-2-iodo-1H-pyrrolo[2,3-b]pyridine; 6-Fluoro-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 6-fluoro-2-iodo-1-(phenylsulfonyl)-; 6-Fluoro-2-iodo-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Benzenesulfonyl)-6-fluoro-2-iodo-1H-pyrrolo[2,3-b]pyridine; 2-Iodo-6-fluoro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1227270-19-0; 6-Fluoro-2-iodo-1-tosyl-7-azaindole (common name variant)
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-6-Fluoro-2-Iodo-7-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.