Description

1-(Phenylsulfonyl)-2-Iodo-6-Methoxy-7-Azaindole is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound is valued for its unique molecular architecture, which combines a sulfonyl-protected indole core with halogen and methoxy substituents, enabling precise chemical modifications. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of new drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging its halogenated indole structure.
• Material Science Research: Serves as a specialized monomer or building block for developing organic electronic materials and advanced polymers.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings for carbon-carbon bond formation.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-purity advanced intermediates.

Basic Information

Product Name	1-(Phenylsulfonyl)-2-Iodo-6-Methoxy-7-Azaindole
CAS No.	1227270-18-9
Molecular Formula	C15H11IN2O3S
Molecular Weight	426.23 g/mol
Synonyms	2-Iodo-6-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 2-iodo-6-methoxy-1-(phenylsulfonyl)-; 6-Methoxy-2-iodo-1-(phenylsulfonyl)-7-azaindole; 2-Iodo-6-methoxy-1-(benzenesulfonyl)-7-azaindole; 7-Azaindole, 2-iodo-6-methoxy-1-(phenylsulfonyl)-; 1-Benzenesulfonyl-2-iodo-6-methoxy-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulfonyl)-2-Iodo-6-Methoxy-7-Azaindole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable and can support regulatory filings with necessary documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.