Description

1-(Phenylsulphonyl)-4-Cyano-7-Azaindole is a high-purity, advanced pharmaceutical intermediate featuring a unique azaindole core functionalized with cyano and phenylsulfonyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule therapeutics. Its specific structure offers valuable versatility for structure-activity relationship (SAR) studies and lead optimization.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and inflammatory disease pathways.
• Kinase Inhibitor Scaffold: Serves as a core structural motif in the design and synthesis of potent and selective kinase inhibitors due to the privileged azaindole architecture.
• Medicinal Chemistry Research: Used extensively in lead identification and optimization campaigns for creating diverse chemical libraries for high-throughput screening.
• Biochemical Probe Development: Employed in the synthesis of tool compounds for studying enzyme function and cellular signaling pathways in academic and industrial R&D.
• Custom Synthesis & Contract Manufacturing: Supplied for custom synthesis projects where specific, high-value intermediates are required for proprietary drug discovery programs.

Basic Information

Product Name	1-(Phenylsulphonyl)-4-Cyano-7-Azaindole
CAS No.	1227269-45-5
Molecular Formula	C16H9N3O2S
Molecular Weight	307.33 g/mol
Synonyms	4-Cyano-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-cyano-1-(phenylsulfonyl)-; 4-Cyano-1-(benzenesulfonyl)-7-azaindole; 1-Benzenesulfonyl-4-cyano-7-azaindole; 7-Azaindole, 1-(phenylsulfonyl)-4-cyano-; 1-(Phenylsulfonyl)-4-cyano-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-4-Cyano-7-Azaindole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.