Description

2-Iodo-5-Azaindole is a high-value halogenated heterocyclic building block, specifically an iodo-substituted azaindole derivative. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel small molecule libraries. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the discovery of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns, particularly for oncology and CNS targets.
• Cross-Coupling Reactions: Serves as a versatile substrate for palladium-catalyzed reactions such as Suzuki, Sonogashira, and Buchwald-Hartwig couplings to introduce the azaindole scaffold.
• Chemical Biology Probes: Employed in the development of molecular probes for studying protein function and biological pathways.
• Agrochemical Research: Potential intermediate in the discovery of new active ingredients for crop protection.
• Material Science: Investigated as a building block for organic electronic materials and functional polymers.

Basic Information

Product Name	2-Iodo-5-Azaindole
CAS No.	1227269-14-8
Molecular Formula	C7H5IN2
Molecular Weight	244.04 g/mol
Synonyms	2-Iodo-1H-pyrrolo[2,3-b]pyridine; 2-Iodo-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 2-iodo-; 2-Iodo-1H-7-azaindole; 2-Iodopyrrolo[2,3-b]pyridine; 2-Iodo-5-aza-indole; 5-Azaindole, 2-iodo-
EINECS	Contact for details

Quality Control

Our 2-Iodo-5-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.