Description

1-(Phenylsulphonyl)-6-Chloro-7-Azaindole-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1227269-03-5. This compound matters as a critical building block in the synthesis of complex, biologically active molecules, offering precise structural control for research and development. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel kinase inhibitors and other targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in oncology and inflammatory disease pathways.
• Kinase Inhibitor Synthesis: Serves as a core scaffold for the construction of potent and selective kinase inhibitors due to its azaindole carboxylic acid structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and pharmacokinetic properties of lead compounds.
• Bioconjugation & Probe Development: The carboxylic acid functionality allows for conjugation to carriers, labels, or other molecules to create biochemical probes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and niche APIs.

Basic Information

Product Name	1-(Phenylsulphonyl)-6-Chloro-7-Azaindole-2-Carboxylic Acid
CAS No.	1227269-03-5
Molecular Formula	C14H9ClN2O4S
Molecular Weight	336.75 g/mol
Synonyms	6-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 6-Chloro-1-(phenylsulfonyl)-7-azaindole-2-carboxylic acid; 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 6-chloro-1-(phenylsulfonyl)-; 1227269-03-5; 6-Chloro-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-6-Chloro-7-Azaindole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.