Description

1-(Phenylsulphonyl)-2-Iodo-4-Nitro-7-Azaindole is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and sulfonylated azaindole structure. This compound is of significant commercial value for its role as a key building block in the synthesis of complex, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and antiviral drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted kinase inhibitors and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization.
• Bioconjugation & Probe Development: The reactive iodine atom makes it suitable for labeling applications and the creation of biochemical probes.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct more complex heterocyclic systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical R&D and scale-up activities.

Basic Information

Product Name	1-(Phenylsulphonyl)-2-Iodo-4-Nitro-7-Azaindole
CAS No.	1227268-92-9
Molecular Formula	C13H8IN3O4S
Molecular Weight	429.19 g/mol
Synonyms	1-(Phenylsulfonyl)-2-iodo-4-nitro-1H-pyrrolo[2,3-b]pyridine; 2-Iodo-4-nitro-1-(phenylsulfonyl)-7-azaindole; 1H-Pyrrolo[2,3-b]pyridine, 2-iodo-4-nitro-1-(phenylsulfonyl)-; 4-Nitro-2-iodo-1-(phenylsulfonyl)-7-azaindole; 1-Benzenesulfonyl-2-iodo-4-nitro-7-azaindole; 2-Iodo-4-nitro-1H-pyrrolo[2,3-b]pyridine 1-(phenylsulfonyl) derivative
EINECS	Contact for details

Quality Control

Every batch of 1-(Phenylsulphonyl)-2-Iodo-4-Nitro-7-Azaindole is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support regulatory filings. A detailed Certificate of Analysis (COA) confirming specifications such as assay (HPLC), related substances, and residual solvents is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon to preserve stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.