Description

1-(Phenylsulfonyl)-5-Bromo-4-Azaindole is a high-purity, advanced pharmaceutical intermediate characterized by its sulfonyl and bromo-substituted azaindole core structure. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of novel drug candidates, particularly kinase inhibitors. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing targeted therapies for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of small molecule kinase inhibitors and other biologically active compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable functional groups.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization via cross-coupling reactions, nucleophilic substitutions, and other transformations.
• Biochemical Tool Compound: Potential use in biochemical assays to study enzyme function and cellular signaling pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Academic Research: Utilized in university laboratories for exploratory organic synthesis and the development of new synthetic methodologies.

Basic Information

Product Name	1-(Phenylsulfonyl)-5-Bromo-4-Azaindole
CAS No.	1227268-74-7
Molecular Formula	C₁₃H₉BrN₂O₂S
Molecular Weight	337.19 g/mol
Synonyms	5-Bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-(phenylsulfonyl)-; 5-Bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Phenylsulfonyl)-5-bromo-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1-(benzenesulfonyl)-1H-7-azaindole; 5-Bromo-1-(phenylsulfonyl)-4-azaindole
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulfonyl)-5-Bromo-4-Azaindole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.