Description

7-Aza-2-Oxindole-6-Carboxylic Acid Methyl Ester is a high-purity heterocyclic building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for the development of novel pharmaceutical agents and bioactive molecules, particularly in kinase inhibitor research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex, nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of potent kinase inhibitors and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Organic Synthesis Building Block: Employed in the synthesis of complex fused heterocyclic systems due to its reactive ester and oxindole core.
• Biochemical Tool Compound Development: Serves as a precursor for probes and inhibitors used in biochemical and cellular assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	7-Aza-2-Oxindole-6-Carboxylic Acid Methyl Ester
CAS No.	1227268-70-3
Molecular Formula	C10H7N3O3
Molecular Weight	217.18 g/mol
Synonyms	Methyl 7-Aza-2-oxo-2,3-dihydro-1H-indole-6-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid, 2,3-dihydro-2-oxo-, methyl ester; 7-Azaoxindole-6-carboxylic acid methyl ester; Methyl 2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate; 6-(Methoxycarbonyl)-7-azaoxindole; CAS 1227268-70-3
EINECS	Contact for details

Quality Control

Our 7-Aza-2-Oxindole-6-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.