Description

1-(Phenylsulphonyl)-6-Chloro-7-Azaindole-2-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its unique azaindole core functionalized with chloro, aldehyde, and phenylsulfonyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule drugs, where its specific scaffold is invaluable for structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent kinase inhibitors targeting various oncology and inflammatory pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns for constructing diverse compound libraries based on the 7-azaindole scaffold.
• Biochemical Probe Development: Serves as a core structure for developing selective chemical probes to study specific enzyme functions and biological mechanisms.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical candidate molecules.
• Academic Research: Utilized in university and institutional labs for fundamental studies in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	1-(Phenylsulphonyl)-6-Chloro-7-Azaindole-2-Carbaldehyde
CAS No.	1227268-67-8
Molecular Formula	C15H9ClN2O3S
Molecular Weight	332.76 g/mol
Synonyms	6-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde; 6-Chloro-1-(phenylsulfonyl)-7-azaindole-2-carboxaldehyde; 1H-Pyrrolo[2,3-b]pyridine-2-carbaldehyde, 6-chloro-1-(phenylsulfonyl)-; 1-(Benzenesulfonyl)-6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-6-Chloro-7-Azaindole-2-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for pharmaceutical R&D and cGMP intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.