Description

1-(Phenylsulphonyl)-2-Chloro-7-Azaindole is a high-purity, advanced pharmaceutical intermediate characterized by its specific azaindole core functionalized with chlorophenylsulfonyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule therapeutics, particularly for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of potent kinase inhibitors and other bioactive molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical space.
• Biochemical Tool Compound: Serves as a reference standard or a precursor for probes used in enzymatic assays and target validation studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	1-(Phenylsulphonyl)-2-Chloro-7-Azaindole
CAS No.	1227268-62-3
Molecular Formula	C13H9ClN2O2S
Molecular Weight	292.74 g/mol
Synonyms	1-(Phenylsulfonyl)-2-chloro-1H-pyrrolo[2,3-b]pyridine; 2-Chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 2-Chloro-1-(phenylsulfonyl)-7-azaindole; 2-Chloro-7-azaindole-1-phenylsulfone; 1H-Pyrrolo[2,3-b]pyridine, 2-chloro-1-(phenylsulfonyl)-; 1-(Benzenesulfonyl)-2-chloro-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-2-Chloro-7-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.