Description

1-(Phenylsulphonyl)-2-Chloro-5-Methyl-7-Azaindole is a high-purity, advanced pharmaceutical intermediate characterized by its unique azaindole core functionalized with chloromethyl and phenylsulfonyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule drugs, where its specific scaffold is valued for modulating biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in oncology and inflammatory disease pathways.
• Kinase Inhibitor Synthesis: Serves as a privileged scaffold for constructing potent and selective kinase inhibitors due to the azaindole structure's ability to form key hydrogen bonds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities and optimize drug-like properties.
• Biochemical Probe Development: Employed in creating tool compounds for target validation and understanding disease mechanisms in biological assays.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for use in cGMP production of active pharmaceutical ingredients (APIs) for clinical trials.
• Academic Research: Utilized in university and institutional labs for pioneering synthetic methodology development and heterocyclic chemistry studies.

Basic Information

Product Name	1-(Phenylsulphonyl)-2-Chloro-5-Methyl-7-Azaindole
CAS No.	1227267-19-7
Molecular Formula	C16H13ClN2O2S
Molecular Weight	332.80 g/mol
Synonyms	2-Chloro-5-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 2-chloro-5-methyl-1-(phenylsulfonyl)-; 2-Chloro-5-methyl-1-(phenylsulfonyl)-7-azaindole; 1-(Phenylsulfonyl)-2-chloro-5-methyl-1H-pyrrolo[2,3-b]pyridine; 2-Chloro-5-methyl-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1-(Phenylsulphonyl)-2-Chloro-5-Methyl-7-Azaindole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.