Description

4-(1-Boc-Piperidin-4-Yloxy)Phenylboronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine moiety and a boronic acid functional group. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl structures, a common motif in drug molecules.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of novel therapeutic agents, particularly in oncology and CNS drug discovery.
• Protease Inhibitor Synthesis: Used in the construction of complex molecules targeting protease enzymes.
• Kinase Inhibitor Development: Integral to creating scaffolds for potential kinase inhibitor candidates.
• Chemical Biology & Probe Development: Employed in the synthesis of chemical probes for studying biological pathways and target validation.
• Process Chemistry & Scale-up: Suitable for use in route scouting and optimization for the commercial manufacturing of APIs.

Basic Information

Product Name	4-(1-Boc-Piperidin-4-Yloxy)Phenylboronic Acid
CAS No.	1224449-07-3
Molecular Formula	C₁₆H₂₄BNO₄
Molecular Weight	305.18 g/mol
Synonyms	4-(1-Boc-4-Piperidyloxy)Benzeneboronic Acid; 4-(1-(tert-Butoxycarbonyl)-4-piperidinyloxy)benzeneboronic Acid; 4-(N-Boc-piperidin-4-yloxy)phenylboronic Acid; 4-(1-Boc-4-piperidyloxy)phenylboronic acid; 4-(1-Boc-piperidin-4-yloxy)benzeneboronic acid; 4-(1-tert-Butoxycarbonylpiperidin-4-yloxy)phenylboronic Acid; BOC-Piperidine-4-(4-boronophenoxy); (4-((1-(tert-Butoxycarbonyl)piperidin-4-yl)oxy)phenyl)boronic Acid
EINECS	Contact for details

Quality Control

Our 4-(1-Boc-Piperidin-4-Yloxy)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent decomposition. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.