Description

3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-Propanol-D6 is a deuterium-labeled derivative of a protected alcohol, featuring a tert-butyldimethylsilyl (TBDMS) ether group. This compound is a crucial stable isotope-labeled intermediate for advanced research and development, enabling precise tracking and quantification in analytical studies. It is primarily utilized by pharmaceutical researchers and academic laboratories engaged in drug metabolism, pharmacokinetics (DMPK), and the synthesis of labeled active pharmaceutical ingredients (APIs).

Application

• Internal Standard for Mass Spectrometry: Serves as a critical quantitative reference standard in LC-MS and GC-MS analysis for drug metabolism and pharmacokinetic (DMPK) studies.
• Synthesis of Deuterated APIs: Used as a key building block in the multi-step synthesis of deuterium-labeled drug candidates for enhanced metabolic stability and clinical research.
• Mechanistic Studies: Enables the tracing of reaction pathways and metabolic fate in complex biological and chemical systems.
• Proteomics & Metabolomics Research: Facilitates accurate relative and absolute quantification in high-throughput screening and biomarker discovery.
• NMR Spectroscopy: Acts as a useful probe in nuclear magnetic resonance studies due to the distinct properties of deuterium.
• Isotope Dilution Analysis: Employed in highly accurate analytical techniques to determine the concentration of target analytes in complex matrices.

Basic Information

Product Name	3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]-1-Propanol-D6
CAS No.	1224439-44-4
Molecular Formula	C9H17D6O2Si
Molecular Weight	193.38 g/mol
Synonyms	3-((tert-Butyldimethylsilyl)oxy)-1-propanol-d6; 3-[(tert-Butyldimethylsilyl)oxy]propan-1-ol-d6; 3-(TBDMS-oxy)-1-propanol-d6; Deuterated 3-(tert-Butyldimethylsilyloxy)-1-propanol; 3-(tert-Butyldimethylsiloxy)-1-propanol-d6; 3-(TBDMSO)-1-propanol-d6; 3-Hydroxypropyl tert-butyldimethylsilyl ether-d6
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-Atom %), chemical purity, and analytical data is provided with every shipment to support your research compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-Atom %)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.