Description

4-[3-(3-Acetyl-1H-Indol-1-Yl)Propanoyl]Piperazin-2-One is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure that is critical for modern drug discovery and development. This compound serves as a versatile and valuable building block for medicinal chemists, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, particularly in the areas of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly for targeted therapies.
• Medicinal Chemistry Research: Used as a core scaffold or building block for constructing complex molecular libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Oncology Drug Development: Employed in the synthesis of potential kinase inhibitors and other targeted anti-cancer agents due to its indole and piperazinone motifs.
• CNS-Active Compound Synthesis: Facilitates the creation of novel molecules for investigating treatments for neurological and psychiatric conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and pharmacology.

Basic Information

Product Name	4-[3-(3-Acetyl-1H-Indol-1-Yl)Propanoyl]Piperazin-2-One
CAS No.	1224169-16-7
Molecular Formula	C₁₇H₁₉N₃O₃
Molecular Weight	313.35 g/mol
Synonyms	1-[3-(3-Acetyl-1H-indol-1-yl)propanoyl]piperazin-2-one; 4-[3-(3-Acetyl-1H-indol-1-yl)propanoyl]-2-piperazinone; 1-(3-(3-Acetyl-1H-indol-1-yl)propanoyl)piperazin-2-one; 2-Piperazinone, 4-[3-(3-acetyl-1H-indol-1-yl)propanoyl]-; CAS 1224169-16-7
EINECS	Contact for details

Quality Control

Our 4-[3-(3-Acetyl-1H-Indol-1-Yl)Propanoyl]Piperazin-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry-standard analytical protocols including HPLC, NMR, and mass spectrometry to verify the chemical identity and quality of the material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under inert atmosphere when not in use to prevent degradation or moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.