Description

5-Chloro-4-(Chloromethyl)Thiophene-2-Carboxylic Acid CAS NO 1223748-49-9 is a high-value, multi-functional heterocyclic building block characterized by its reactive chloromethyl and carboxylic acid groups. This compound is essential for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where it serves as a key precursor. It is primarily sought after by research institutions and industrial manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for enhanced biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of conductive polymers, organic semiconductors, and specialty coatings.
• Chemical Biology & Proteomics: Employed as a versatile linker or tagging reagent in bioconjugation and probe development due to its reactive handles.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-Chloro-4-(Chloromethyl)Thiophene-2-Carboxylic Acid
CAS No.	1223748-49-9
Molecular Formula	C7H4Cl2O2S
Molecular Weight	223.08 g/mol
Synonyms	5-Chloro-4-(chloromethyl)-2-thiophenecarboxylic acid; 2-Thiophenecarboxylic acid, 5-chloro-4-(chloromethyl)-; 4-(Chloromethyl)-5-chlorothiophene-2-carboxylic acid; 5-Chloro-4-chloromethylthiophene-2-carboxylic acid; 1223748-49-9; Thiophene-2-carboxylic acid, 5-chloro-4-(chloromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-(Chloromethyl)Thiophene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.