Description

3A-Hydroxymethyl-Hexahydro-Cyclopenta[C]Pyrrole-2-Carboxylic Acid tert-Butyl Ester is a sophisticated chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) due to its rigid, fused bicyclic structure and protected functional groups. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in central nervous system (CNS) and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing novel molecular libraries in drug discovery programs.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of target molecules.
• Asymmetric Synthesis: Exploits its inherent chirality for the stereoselective construction of other complex molecules.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	3A-Hydroxymethyl-Hexahydro-Cyclopenta[C]Pyrrole-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1223748-37-5
Molecular Formula	C14H23NO3
Molecular Weight	253.34 g/mol
Synonyms	tert-Butyl 3-(hydroxymethyl)octahydrocyclopenta[c]pyrrole-2-carboxylate; (3aS,7aR)-tert-Butyl 3-(hydroxymethyl)hexahydro-1H-cyclopenta[c]pyrrole-2(3H)-carboxylate; 3-(Hydroxymethyl)octahydrocyclopenta[c]pyrrole-2-carboxylic Acid tert-Butyl Ester; 3a-Hydroxymethyl-hexahydro-cyclopenta[c]pyrrole-2-carboxylic Acid tert-Butyl Ester; 3a-Hydroxymethyl-octahydro-cyclopenta[c]pyrrole-2-carboxylic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and purity suitable for advanced pharmaceutical applications. All batches are characterized by comprehensive analytical methods including HPLC, GC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support regulatory filings with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.