Description

trans-1-(Boc-Amino)-4-(Bromomethyl)Cyclohexane, 97% is a high-purity, bifunctional organic building block featuring both a tert-butoxycarbonyl (Boc)-protected amine and a reactive bromomethyl group. This compound is essential for the efficient synthesis of complex molecules, enabling precise molecular assembly in medicinal chemistry and advanced materials research. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for constructing peptide mimetics, linker molecules, and as a key intermediate in the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in creating constrained peptide analogs and bioactive molecules.
• Peptidomimetic Synthesis: Used to introduce cyclohexane-based scaffolds and spacer/linker elements into peptide chains to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Serves as a versatile precursor for labeling reagents and affinity probes due to its orthogonal reactive sites (Boc-amine for deprotection/functionalization and bromomethyl for alkylation).
• Material Science: Employed in the preparation of functionalized polymers and dendrimers where the cyclohexane core provides rigidity.
• Cross-Coupling Reactions: The bromomethyl group can be utilized in various metal-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Protecting Group Chemistry: The Boc group offers a standard, acid-labile protection strategy for amines during multi-step synthetic sequences.

Basic Information

Product Name	trans-1-(Boc-Amino)-4-(Bromomethyl)Cyclohexane, 97%
CAS No.	1222709-30-9
Molecular Formula	C₁₂H₂₂BrNO₂
Molecular Weight	292.21 g/mol
Synonyms	trans-4-(Bromomethyl)-1-[(tert-butoxycarbonyl)amino]cyclohexane; 1-N-Boc-4-(bromomethyl)cyclohexylamine (trans); trans-1-((tert-Butoxycarbonyl)amino)-4-(bromomethyl)cyclohexane; trans-1-Amino-4-(bromomethyl)cyclohexane tert-butylcarbamate; trans-N-Boc-4-(bromomethyl)cyclohexanamine; (1r,4r)-4-(Bromomethyl)cyclohexylcarbamic acid tert-butyl ester; tert-Butyl ((1r,4r)-4-(bromomethyl)cyclohexyl)carbamate
EINECS	Contact for details

Quality Control

Our trans-1-(Boc-Amino)-4-(Bromomethyl)Cyclohexane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the specified 97% minimum purity. Certificates of Analysis (COA) detailing all test results are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.