Description

1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazol-3-Amine (CAS NO 1220220-18-7) is a high-value, functionalized indazole derivative featuring a pinacol boronate ester group, making it a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for targeted therapies and kinase inhibitors.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators through structure-activity relationship (SAR) studies.
• Material Science: Employed in the creation of organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of molecular probes and enzyme inhibitors.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and catalysis research within R&D laboratories.
• Custom Synthesis & Scale-Up: Provides a reliable starting point for contract manufacturing organizations (CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazol-3-Amine
CAS No.	1220220-18-7
Molecular Formula	C₁₄H₂₀BN₃O₂
Molecular Weight	273.14 g/mol
Synonyms	3-Amino-1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 1-Methyl-5-(pinacolatoboryl)-1H-indazol-3-amine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-indazol-3-amine; 1-Methyl-5-(pinacol boronate)-1H-indazol-3-amine; 1220220-18-7; 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-3-ylamine; 3-Amino-1-methyl-5-(pinacolatoboryl)indazole
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazol-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided to guarantee the material meets the stringent requirements for research and commercial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere to prevent degradation and moisture absorption. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.