Description

2-(3-Piperidinylmethyl)-1,2,3,4-Tetrahydroisoquinoline Dihydrochloride is a high-purity, complex organic salt primarily utilized as a critical pharmaceutical intermediate. This compound matters for its role in the synthesis of advanced active pharmaceutical ingredients (APIs) and novel drug candidates, particularly within central nervous system (CNS) research. Pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) require this building block for its specific structural features that enable the development of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly for neurological and psychiatric targets.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in multi-step synthetic routes for final API production under GMP conditions.
• Biochemical Research: Employed as a ligand or probe in biochemical assays to study receptor interactions and enzyme inhibition.
• Fine Chemical Manufacturing: Supplied to custom synthesis and contract manufacturing organizations (CMOs) for specialized production runs.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	2-(3-Piperidinylmethyl)-1,2,3,4-Tetrahydroisoquinoline Dihydrochloride
CAS No.	1220019-49-7
Molecular Formula	C15H22N2·2HCl
Molecular Weight	311.27 g/mol (free base: 230.35 g/mol)
Synonyms	1,2,3,4-Tetrahydro-2-[(3-piperidinyl)methyl]isoquinoline dihydrochloride; 2-(Piperidin-3-ylmethyl)-1,2,3,4-tetrahydroisoquinoline dihydrochloride; 2-(3-Piperidylmethyl)-1,2,3,4-tetrahydroisoquinoline dihydrochloride; THIQ-Piperidinylmethyl Dihydrochloride; CAS 1220019-49-7
EINECS	Contact for details

Quality Control

Our 2-(3-Piperidinylmethyl)-1,2,3,4-Tetrahydroisoquinoline Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and heavy metals to ensure it meets stringent specifications for pharmaceutical use. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all test results against agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.