Description

2,2,3,3,5,5,6,6-Octadeuterio-1-[(2,3,4-Trimethoxyphenyl)Methyl]Piperazine is a deuterium-labeled analog of a key piperazine derivative, serving as a critical internal standard and tracer in advanced analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry (MS) and nuclear magnetic resonance (NMR) analyses. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and mechanistic biochemical research.

Application

• Internal Standard for Quantitative LC-MS/MS: Provides unmatched accuracy in the quantification of the non-deuterated parent compound in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a stable isotope-labeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of new chemical entities.
• Proteomics and Biomarker Discovery: Enables precise relative and absolute quantification of proteins and peptides in isotope-coded affinity tag (ICAT) and other mass-tagging techniques.
• Mechanistic Biochemical Research: Acts as a tracer to elucidate enzymatic pathways, reaction mechanisms, and metabolic flux in vitro and in vivo.
• Quality Control and Method Validation: Serves as a certified reference material (CRM) to validate analytical methods, ensuring compliance with GLP and GMP guidelines.
• NMR Spectroscopy Solvent Studies: Useful as a deuterated shift reagent or for creating specific deuterium-enriched environments in NMR analysis.

Basic Information

Product Name	2,2,3,3,5,5,6,6-Octadeuterio-1-[(2,3,4-Trimethoxyphenyl)Methyl]Piperazine
CAS No.	1219908-67-4
Molecular Formula	C15D8H16N2O3
Molecular Weight	280.36 g/mol (deuterated form)
Synonyms	1-[(2,3,4-Trimethoxyphenyl)methyl]piperazine-d8; Piperazine-d8, 1-[(2,3,4-trimethoxyphenyl)methyl]-; Deuterated 1-(2,3,4-Trimethoxybenzyl)piperazine; 1-(2,3,4-Trimethoxybenzyl)piperazine-d8; Octadeutero-1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 1-(2,3,4-Trimethoxybenzyl)-piperazine (deuterated, 2,2,3,3,5,5,6,6-d8); Deuterated TMB-Piperazine; Stable Isotope Labeled 1-(2,3,4-Trimethoxybenzyl)piperazine
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is produced and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with comprehensive testing including assay by quantitative NMR (qNMR) or HPLC, isotopic purity by mass spectrometry, and confirmation of structure by 1H NMR and 13C NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical parameters to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider sealing under an inert atmosphere such as argon or nitrogen to maintain optimal stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity (NMR)	≥ 97%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.