Description

9-Amino-1,2,3,4-Tetrahydroacridin-1-Ol-D3 Maleate is a high-purity, deuterated chemical compound primarily used as a critical reference standard and intermediate in pharmaceutical research and development. Its core value lies in enabling precise analytical work, including method development, validation, and metabolic studies, due to its stable isotopic labeling. This product is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors who require reliable, well-characterized materials for drug discovery and development processes.

Application

• Pharmaceutical Reference Standard: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and other analytical techniques for accurate quantification of non-deuterated analogs in biological matrices.
• Metabolic Pathway Tracing: Employed in pharmacokinetic and drug metabolism studies to track and identify metabolites, leveraging the deuterium label for enhanced detection and differentiation.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the synthesis of deuterated drug candidates, a growing area in medicinal chemistry aimed at improving metabolic stability and patent life.
• Analytical Method Development: Critical for developing and validating robust, sensitive, and specific analytical methods for quality control and regulatory submissions.
• Isotope Dilution Mass Spectrometry (IDMS): Provides the labeled analyte necessary for this highly accurate quantitative technique, which is a gold standard in clinical and forensic toxicology.
• Biochemical Research: Utilized in mechanistic studies to understand enzyme interactions and binding affinities without significantly altering the chemical properties of the parent molecule.

Basic Information

Item	Details
Product Name	9-Amino-1,2,3,4-Tetrahydroacridin-1-Ol-D3 Maleate
CAS No.	1219806-48-0
Molecular Formula	C17H14D3N2O5
Molecular Weight	332.34 g/mol (approx.)
Synonyms	9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d3 (Z)-butenedioate; 1,2,3,4-Tetrahydro-9-aminoacridin-1-ol-d3 maleate; Deuterated Tacrine metabolite standard; 9-Amino-1,2,3,4-tetrahydro-1-acridinol-d3 maleate salt; THA-d3 maleate; 9-Amino-1,2,3,4-tetrahydroacridine-1-ol-d3 maleate; Tacrine-d3 metabolite maleate
EINECS	Contact for details

Quality Control

Every batch of 9-Amino-1,2,3,4-Tetrahydroacridin-1-Ol-D3 Maleate is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments, ensuring identity, purity, and isotopic enrichment meet stringent requirements. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay, isotopic purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.