Description

Tris Maleate-D15 [1:1 Mixture Of Maleic Acid And Tris(Hydroxymethyl)Aminomethane-D11 Salt] is a high-purity, deuterated salt complex specifically designed for advanced analytical and research applications. This compound matters as a critical internal standard and reference material for mass spectrometry and NMR spectroscopy, ensuring precise quantification and method validation in complex matrices. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and agrochemical sectors who require the highest level of isotopic purity and chemical stability for their deuterium-labeling studies and metabolic research.

Application

• Internal Standard for LC-MS/MS: Used for the accurate quantification of tris(hydroxymethyl)aminomethane (Tris) and related compounds in biological and environmental samples.
• NMR Spectroscopy Solvent & Reagent: Serves as a deuterated buffer component or chemical shift reference in nuclear magnetic resonance studies.
• Metabolic Pathway Tracing: Employed in stable isotope labeling experiments (SIL) to track biochemical pathways and drug metabolism in vivo and in vitro.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in drug substances and products.
• Proteomics & Biomarker Research: Facilitates precise protein quantification and the discovery of disease biomarkers through isotope-coded affinity tag (ICAT) or similar techniques.
• Quality Control Reference Material: Provides a certified standard for calibrating analytical instruments and validating analytical methods in GMP/GLP environments.

Basic Information

Item	Detail
Product Name	Tris Maleate-D15 [1:1 Mixture Of Maleic Acid And Tris(Hydroxymethyl)Aminomethane-D11 Salt]
CAS No.	1219806-43-5
Molecular Formula	C7H2D15NO7
Molecular Weight	Contact for details
Synonyms	Tris-d11 Maleate-d4; Deuterated Tris Maleate Buffer Salt; Tris(Hydroxymethyl-d3)aminomethane-d8 Maleate-d4; (2,2,2-Trideuterio-1,3-bis(trideuteriomethyl)-2-(trideuteriomethylamino)propyl) (2,3,4-Trideuterio-4-oxobut-2-enoate); TRIS-D11 Maleic Acid-d4 Salt; Aminotris(methylene-d3-d3)methane-d8 Maleate-d4; Deuterated Trometamol Maleate
EINECS	Contact for details

Quality Control

Our Tris Maleate-D15 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic purity and chemical identity. Certificates of Analysis (COA) are provided, detailing batch-specific results for isotopic enrichment, chemical purity, and other critical parameters to ensure compliance with your research or quality control protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of atmospheric moisture, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.