Description

trans-4-Hydroxy-2-Hexenal--D5 Dimethyl Acetal is a deuterated isotopologue of a key lipid peroxidation metabolite, specifically designed for use as an analytical standard and research chemical. This compound is critical for enabling precise quantification and metabolic pathway tracing in studies of oxidative stress and related biological processes. It is primarily utilized by researchers and analytical laboratories in the pharmaceutical, biotechnology, and life science sectors for advanced mass spectrometry, NMR spectroscopy, and biomarker discovery.

Application

• Analytical Reference Standard: Primary use as a certified internal standard for the accurate quantification of 4-hydroxy-2-hexenal (4-HHE) and related aldehydes via LC-MS/MS and GC-MS.
• Biomarker Research: Tracing and studying the role of lipid peroxidation products in diseases associated with oxidative stress, such as cardiovascular disorders, neurodegenerative conditions, and diabetes.
• Metabolic Pathway Analysis: Investigating the metabolism and detoxification pathways of reactive aldehydes in in vitro and in vivo models using deuterium labeling.
• Food and Nutritional Science: Research into lipid oxidation in food products and the subsequent formation of potentially bioactive or harmful compounds.
• Toxicology Studies: Assessing the biological impact and adduct formation of reactive carbonyl species in cellular and animal models.
• Method Development & Validation: Essential for developing and validating highly sensitive and specific analytical methods in clinical and research laboratories.

Basic Information

Product Name	trans-4-Hydroxy-2-Hexenal--D5 Dimethyl Acetal
CAS No.	1219806-40-2
Molecular Formula	C8H11D5O3
Molecular Weight	163.24 g/mol (for C8H11D5O3)
Synonyms	4-HHE-d5 Dimethyl Acetal; (2E)-4-Hydroxyhex-2-enal-1,1,2,3,3-d5 Dimethyl Acetal; 4-Hydroxy-2-hexenal-d5 DMA; Deuterated 4-HHE Dimethyl Acetal; Lipid Peroxidation Product-d5; trans-4-Hydroxy-2-hexenal-1,1,2,3,3-d5 dimethyl acetal; 4-Oxohexanal-d5 dimethyl acetal (tautomer); HHE-d5 Dimethyl Acetal
EINECS	Contact for details

Quality Control

Every batch of trans-4-Hydroxy-2-Hexenal--D5 Dimethyl Acetal is produced and analyzed under strict quality management protocols to ensure the highest standards of isotopic purity and chemical identity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for isotopic enrichment, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under an inert atmosphere after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (GC)	≥ 98%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.