Description

N,o-Bis(Trimethyl-D9-Silyl)Trifluoroacetamide is a high-purity, deuterated silylation reagent critical for analytical chemistry. Its primary value lies in its role as a derivatization agent for gas chromatography-mass spectrometry (GC-MS), where it enhances the volatility and thermal stability of target analytes while introducing a stable isotopic label for precise quantification. This compound is essential for researchers and quality control laboratories in the pharmaceutical, environmental testing, and metabolomics fields who require the highest levels of accuracy and sensitivity in their trace analysis workflows.

Application

• Derivatization Agent for GC-MS Analysis: Used to silylate polar functional groups (e.g., -OH, -COOH, -NH) in compounds like drugs, metabolites, and environmental contaminants to make them amenable for gas chromatographic separation and mass spectrometric detection.
• Stable Isotope-Labeled Internal Standard: The deuterium (D9) label allows for the preparation of isotopically labeled derivatives, which serve as ideal internal standards for quantitative mass spectrometry, minimizing matrix effects and improving data accuracy.
• Pharmaceutical Impurity Profiling and Metabolite Identification: Enables the sensitive detection and structural elucidation of drug metabolites and process-related impurities in complex biological matrices.
• Clinical and Forensic Toxicology: Facilitates the precise quantification of drugs of abuse, therapeutic drugs, and their metabolites in blood, urine, and other bodily fluids.
• Metabolomics and Biomarker Discovery: Used in the preparation of samples for comprehensive profiling of small molecule metabolites in cells, tissues, or biofluids to identify disease biomarkers.
• Environmental Analysis: Applied in the detection and quantification of trace-level pollutants, pesticides, and endocrine-disrupting chemicals in water, soil, and air samples.
• Food Safety and Quality Control: Assists in the analysis of mycotoxins, veterinary drug residues, and other contaminants in food products.

Basic Information

Product Name	N,o-Bis(Trimethyl-D9-Silyl)Trifluoroacetamide
CAS No.	1219806-39-9
Molecular Formula	C8D9F3N1O1Si2
Molecular Weight	285.42 g/mol
Synonyms	BSTFA-d9; N,O-Bis(trimethylsilyl)trifluoroacetamide-d9; Deuterated BSTFA; BSA-d9 (common abbreviation); N,O-Bis(trimethyl-d9-silyl)trifluoroacetamide; MSTFA-d9 (related compound); TMS-d9 derivatization reagent; Bis(trimethylsilyl)trifluoroacetamide-d27 (fully deuterated form)
EINECS	Contact for details

Quality Control

Our N,o-Bis(Trimethyl-D9-Silyl)Trifluoroacetamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity, which is critical for accurate quantitative MS applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment, chemical purity, and absence of interfering substances. We adhere to relevant industry guidelines for analytical reagents to support your compliance needs in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (D9)	≥ 99.0 atom % D
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.