Description

2-(Diethylamino)Ethyl-D4 Chloride Hcl is a deuterated derivative of a key pharmaceutical intermediate, where four hydrogen atoms are replaced with deuterium, a stable isotope. This deuteration is critical for enhancing metabolic stability and enabling advanced pharmacokinetic studies in drug discovery and development. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for creating deuterated active pharmaceutical ingredients (APIs) and for use as an internal standard in mass spectrometry.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial precursor for the development of deuterium-labeled drugs, which can offer improved metabolic profiles and reduced side effects.
• Metabolic and Pharmacokinetic (DMPK) Studies: Used as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS analyses for accurate quantification and tracing of metabolites.
• Mechanistic Biochemistry Research: Employed in isotope effect studies to elucidate reaction mechanisms and enzymatic pathways.
• Pharmaceutical Intermediate: Functions as a key chiral building block in the multi-step synthesis of complex therapeutic molecules.
• Proteomics and Biomarker Discovery: Facilitates quantitative proteomics through isotope-coded affinity tag (ICAT) or other labeling strategies.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and contract manufacturers specializing in novel drug development programs.

Basic Information

Product Name	2-(Diethylamino)Ethyl-D4 Chloride Hcl
CAS No.	1219805-94-3
Molecular Formula	C6D4H10ClN•HCl
Molecular Weight	188.14 g/mol (for monoisotopic mass)
Synonyms	2-(Diethylamino)ethyl-d4 chloride hydrochloride; N,N-Diethyl-2-aminoethane-d4 chloride hydrochloride; Deutero-N,N-Diethyl-2-chloroethylamine hydrochloride; (2-Chloroethyl-d4)diethylamine hydrochloride; DEAE-d4 Chloride HCl; 1-Chloro-2-(diethylamino)ethane-d4 hydrochloride; N,N-Diethyl-2-chloroethylamine-d4 hydrochloride; 2-Chloro-N,N-diethylethanamine-d4 hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2-(Diethylamino)Ethyl-D4 Chloride Hcl is manufactured and tested under strict quality management systems. We provide comprehensive analytical data including deuterium enrichment (D%) verified by NMR and MS, chemical purity by HPLC/GC, and confirmation of structure and isotopic pattern. Certificates of Analysis (COA) detailing all specifications and test results are available upon request and are essential for regulatory filings in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and deuteration pattern
Purity (HPLC/GC)	≥ 98.0%
Deuterium Enrichment (D%)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.