Description

Nicotine-D7 (n-Methyl-D3, Pyridine-D4) is a stable isotope-labeled analog of nicotine, where seven hydrogen atoms are replaced with deuterium. This compound is essential as an internal standard in quantitative mass spectrometry, providing unmatched accuracy and reliability for analytical measurements. It is primarily required by pharmaceutical R&D laboratories, forensic toxicology units, and agrochemical companies for metabolic studies, pharmacokinetic profiling, and high-precision residue analysis.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the accurate quantification of nicotine and its metabolites in complex biological matrices.
• Pharmacokinetic and Metabolic Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to track the fate of nicotine in preclinical and clinical studies.
• Forensic Toxicology and Clinical Diagnostics: Enables precise measurement of nicotine and cotinine levels in blood, urine, or saliva for substance abuse testing and exposure assessment.
• Agrochemical and Environmental Analysis: Facilitates the detection and quantification of nicotine-related compounds in environmental samples and agricultural products.
• Pharmaceutical Reference Standard: Acts as a certified reference material for method development, validation, and quality control in analytical laboratories.
• Biochemical Research: Used in studies investigating nicotinic acetylcholine receptor binding and related neurological pathways.

Basic Information

Product Name	Nicotine-D7 (n-Methyl-D3, Pyridine-D4)
CAS No.	1219805-86-3
Molecular Formula	C₁₀H₇D₇N₂
Molecular Weight	169.25 g/mol
Synonyms	Deuterated Nicotine; Nicotine-d7; (S)-3-(1-Methyl-2-pyrrolidinyl-d3)pyridine-d4; (S)-Nicotine-d7; (-)-Nicotine-d7; 1-Methyl-2-(3-pyridyl-d4)pyrrolidine-d3; Isotopically Labeled Nicotine; Nicotine Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Nicotine-D7 is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and solvent residues, ensuring compliance with the stringent requirements of analytical and pharmaceutical reference standards. Our products are suitable for use in regulated environments under GMP/GLP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is light-sensitive (store away from light) and highly volatile. For long-term storage, keep under inert atmosphere in a freezer (-20°C).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.