Description

n-Acetyl-D3-Glycine-2,2-D2 is a stable isotope-labeled derivative of N-acetylglycine, specifically deuterated at the methyl and glycine positions. This compound is essential for advanced analytical research, providing a critical internal standard for precise quantification in mass spectrometry-based metabolomic and proteomic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on biomarker discovery, drug metabolism, and pharmacokinetic (PK/ADME) studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for analyzing endogenous metabolites.
• Biomarker Research: Used in metabolic pathway tracing and the accurate measurement of glycine and related acetylated amino acids in biological samples.
• Drug Metabolism & Pharmacokinetics (DMPK): Enables precise tracking of drug candidates and their metabolites in in vitro and in vivo ADME studies.
• Proteomics & Metabolomics: Facilitates high-precision relative and absolute quantification in large-scale profiling studies of proteins and small molecules.
• Stable Isotope Labeling: Acts as a building block or tracer in the synthesis of more complex deuterated compounds for research.
• Quality Control in Clinical Diagnostics: Supports the development and validation of robust clinical assays for metabolic disorders.

Basic Information

Product Name	n-Acetyl-D3-Glycine-2,2-D2
CAS No.	1219805-82-9
Molecular Formula	C4D5H4NO3
Molecular Weight	121.12 g/mol (for deuterated form)
Synonyms	N-Acetyl-d3-glycine-2,2-d2; Deuterated N-Acetylglycine; N-Acetylglycine-d5; Acetamidoacetic-d5 acid; (2,2-Dideutero-2-(trideuterioacetamido)acetic acid); N-(Trideuterioacetyl)-2,2-dideuterioglycine; Stable Isotope Labeled N-Acetylglycine; Glycine, N-acetyl-, methyl-d3, 2,2-d2
EINECS	Contact for details

Quality Control

Our n-Acetyl-D3-Glycine-2,2-D2 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D%), chemical purity, and analytical results from techniques such as NMR and HPLC-MS. We adhere to relevant industry guidelines for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.