Description

3-Hydroxy-1,5-Pentanedioic--D5 Acid is a high-purity, deuterium-labeled analog of 3-hydroxyglutaric acid, offering a stable isotopic tracer for advanced research and analytical applications. This compound is essential for metabolic pathway studies, providing critical insights into biochemical processes without interference from endogenous compounds. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in mass spectrometry, NMR spectroscopy, and drug metabolism and pharmacokinetics (DMPK) studies.

Application

• As a stable isotope-labeled internal standard for the precise quantification of 3-hydroxyglutaric acid in biological matrices via LC-MS/MS.
• Use in NMR spectroscopy as a deuterated probe for studying metabolic flux and enzyme mechanisms.
• A key tracer in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug candidates.
• Research into inborn errors of metabolism, particularly related to glutaric aciduria and other organic acidemias.
• Development and validation of clinical diagnostic assays for metabolic disorders.
• Biochemical research involving the Krebs cycle and related metabolic pathways.

Basic Information

Product Name	3-Hydroxy-1,5-Pentanedioic--D5 Acid
CAS No.	1219805-72-7
Molecular Formula	C5H3D5O5
Molecular Weight	169.13 g/mol (for D5 labeled form)
Synonyms	3-Hydroxyglutaric Acid-d5; 3-Hydroxyglutaric Acid (D5); 3-Hydroxy-1,5-pentanedioic-2,2,3,4,4-d5 Acid; 3-Hydroxypentanedioic-2,2,3,4,4-d5 Acid; Deuterated 3-Hydroxyglutaric Acid; [2,2,3,4,4-2H5]-3-Hydroxyglutaric Acid
EINECS	Contact for details

Quality Control

Every batch of 3-Hydroxy-1,5-Pentanedioic--D5 Acid is manufactured under strict quality systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity to meet the exacting standards of research and analytical applications. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.