Description

4-Aminohippuric-D4 Acid is a stable isotope-labeled analog of 4-aminohippuric acid, where four hydrogen atoms are replaced by deuterium. This compound is a critical internal standard for the precise quantification of 4-aminohippuric acid in biological matrices using mass spectrometry. It is primarily required by pharmaceutical research, clinical diagnostic, and analytical chemistry laboratories for pharmacokinetic studies, renal function testing, and method development.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for accurate quantification of 4-aminohippuric acid in plasma, serum, and urine samples.
• Pharmacokinetic and Metabolism Studies: Used in drug development to trace the absorption, distribution, metabolism, and excretion (ADME) of related compounds.
• Renal Function and Diagnostic Assays: Serves as a reference standard in clinical assays measuring effective renal plasma flow (ERPF).
• Biomarker Research: Employed in metabolomics and proteomics research for precise biomarker validation.
• Method Development and Validation: A key component for developing and validating robust, GLP-compliant analytical methods in regulated environments.
• Isotope Dilution Mass Spectrometry (IDMS): Used as a spike-in standard for high-accuracy measurements, minimizing matrix effects and instrument variability.

Basic Information

Product Name	4-Aminohippuric-D4 Acid
CAS No.	1219805-41-0
Molecular Formula	C9H4D4N2O3
Molecular Weight	198.20 g/mol
Synonyms	4-Amino-D4-hippuric Acid; N-(4-Aminobenzoyl)-D4-glycine; 4-Aminohippuric Acid-d4; PAH-d4; p-Aminohippuric Acid-d4; (4-Amino-D4-benzamido)acetic Acid; 4-AH-D4; 1219805-41-0
EINECS	Contact for details

Quality Control

Our 4-Aminohippuric-D4 Acid is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic purity (by MS), and chemical purity. We support research and development under GMP/GLP guidelines, and custom synthesis to meet specific purity or packaging requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach ambient temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.