Description

3-Methyl-D3-Butyric--D4 Acid CAS NO 1219805-32-9 is a high-purity, isotopically labeled derivative of isovaleric acid, featuring deuterium atoms at specific positions. This compound is essential as a stable isotope-labeled internal standard for precise quantitative analysis in mass spectrometry, ensuring accurate and reliable results. It is primarily required by analytical laboratories and research institutions in the pharmaceutical, metabolomics, and environmental testing sectors for method development and validation.

Application

• As a stable isotope-labeled internal standard (SIL-IS) for the accurate quantification of isovaleric acid and related metabolites in biological samples via GC-MS or LC-MS.
• In pharmaceutical research and development for pharmacokinetic (PK) and pharmacodynamic (PD) studies, enabling precise tracking of drug metabolites.
• For clinical diagnostics, particularly in screening for inborn errors of metabolism such as isovaleric acidemia.
• Use in nutritional and metabolomics studies to investigate fatty acid metabolism and gut microbiome-host interactions.
• Application in environmental analysis for tracing and quantifying volatile fatty acids in complex matrices.
• As a critical reagent in method development and validation to meet regulatory standards for data accuracy and reproducibility.

Basic Information

Product Name	3-Methyl-D3-Butyric--D4 Acid
CAS No.	1219805-32-9
Molecular Formula	C5H4D7O2
Molecular Weight	107.17 g/mol (approx.)
Synonyms	Isovaleric-3,4,4,4-d4-3-methyl-d3 Acid; (3-Methyl-d3)butyric-4,4,4-d3 Acid; 3-Methylbutyric-d7 Acid; Deuterated Isovaleric Acid; 3-Methyl[2H3]butyric-4,4,4-[2H3]acid; Isobutylcarboxylic-d7 Acid; 3-Methyl-D3-Butanoic-D4 Acid
EINECS	Contact for details

Quality Control

Every batch of 3-Methyl-D3-Butyric--D4 Acid is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR, MS, and HPLC to confirm identity, assay, and isotopic enrichment. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.