Description

Dl-Homocysteine Thiolactone--D4 Hcl is a high-purity, deuterium-labeled derivative of homocysteine thiolactone hydrochloride, serving as a critical internal standard for precise quantitative analysis. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in mass spectrometry-based assays, particularly in metabolomic and clinical research. It is primarily utilized by analytical laboratories, pharmaceutical R&D departments, and diagnostic manufacturers focused on cardiovascular disease, metabolic disorders, and nutritional status biomarkers.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of homocysteine and related metabolites in complex biological matrices like plasma, serum, and urine.
• Metabolomics Research: Used in stable isotope dilution assays to study sulfur amino acid metabolism pathways and their dysregulation in disease states.
• Clinical Diagnostics Development: Critical for developing and validating high-sensitivity diagnostic tests for hyperhomocysteinemia, a risk factor for cardiovascular and neurological conditions.
• Pharmaceutical Analysis: Employed in pharmacokinetic and pharmacodynamic studies of drugs that interact with homocysteine metabolism.
• Nutritional Science Studies: Facilitates precise measurement of homocysteine levels in studies investigating vitamin B12, B6, and folate deficiencies.
• Biomarker Verification & Validation: Supports the rigorous verification process for homocysteine as a clinical biomarker in accordance with regulatory guidelines.

Basic Information

Product Name	Dl-Homocysteine Thiolactone--D4 Hcl
CAS No.	1219805-31-8
Molecular Formula	C4H3D4ClNO2S
Molecular Weight	177.66 g/mol (for D4 isotopologue)
Synonyms	DL-Homocysteine Thiolactone-d4 Hydrochloride; 2-Amino-4,4,4',4'-tetradeuterio-4-mercaptobutyric acid γ-lactone hydrochloride; Homocysteine thiolactone-d4 HCl; (RS)-Homocysteine thiolactone-d4 hydrochloride; Deuterated Homocysteine Thiolactone HCl; Hcy-thiolactone-d4 HCl; Isotopic Internal Standard for Homocysteine; 3,3,5,5-D4-DL-Homocysteine thiolactone hydrochloride
EINECS	Contact for details

Quality Control

Our Dl-Homocysteine Thiolactone--D4 Hcl is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity by HPLC, and confirmation of structure. We adhere to industry best practices for reference material production, ensuring consistency and reliability for your most sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity (by titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.