Description

(±)-Ketoprofen-D4 CAS NO 1219805-29-4 is a deuterated internal standard of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen, where four hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for ensuring the accuracy and reliability of quantitative mass spectrometry analyses in complex biological matrices. It is an essential tool for pharmaceutical R&D, clinical research, and forensic toxicology laboratories requiring precise pharmacokinetic and metabolic studies. The compound enables researchers to achieve superior analytical precision by correcting for sample preparation losses and instrument variability.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the accurate LC-MS/MS quantification of ketoprofen in plasma, serum, urine, and tissue homogenates.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic & Clinical Toxicology: Used in method development and routine testing for the confirmation and quantification of ketoprofen in forensic and workplace drug testing.
• Drug Impurity & Degradation Profiling: Assists in the identification and quantification of related substances and degradation products during pharmaceutical development and stability testing.
• Method Development & Validation: Provides a critical reference for developing, optimizing, and validating robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Environmental & Food Safety Analysis: Applied in trace analysis for monitoring pharmaceutical residues in environmental waters and food products.

Basic Information

Product Name	(±)-Ketoprofen-D4
CAS No.	1219805-29-4
Molecular Formula	C16H10D4O3
Molecular Weight	258.31 g/mol
Synonyms	Ketoprofen-d4; 2-(3-Benzoylphenyl)propionic-3,3,4,4-d4 acid; 3,3,4,4-Tetradeuterioketoprofen; (±)-2-(3-Benzoylphenyl)propionic-d4 acid; DL-Ketoprofen-d4; Ketoprofen (phenyl-d4); RS-Ketoprofen-d4; Ketoprofen Internal Standard (d4)
EINECS	Contact for details

Quality Control

Our (±)-Ketoprofen-D4 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, isotopic enrichment (typically ≥98 atom % D), and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment. We support compliance with GMP/GLP principles for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.