Description

3,4,5-Trimethoxybenzaldehyde-D3 is a deuterium-labeled derivative of the versatile synthetic intermediate 3,4,5-trimethoxybenzaldehyde. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, providing superior accuracy and reliability in analytical measurements. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, agrochemical, and analytical chemistry sectors who require precise quantification of its non-deuterated counterpart or related metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the accurate quantification of 3,4,5-trimethoxybenzaldehyde and its derivatives in complex biological or chemical matrices.
• Pharmaceutical Research & Development: Used in pharmacokinetic (PK) and metabolism studies for drugs where the trimethoxybenzaldehyde moiety is a key structural component.
• Metabolite Identification: Aids in the identification and quantification of drug metabolites in in vitro and in vivo studies.
• Analytical Method Development: Critical for developing and validating robust, high-precision analytical methods in compliance with regulatory guidelines (e.g., FDA, ICH).
• Chemical Synthesis Tracing: Can be employed as a tracer in mechanistic studies of chemical reactions involving the aldehyde functional group.
• Quality Control & Assurance: Ensures batch-to-batch consistency and purity assessment in the production of fine chemicals and active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3,4,5-Trimethoxybenzaldehyde-D3
CAS No.	1219805-17-0
Molecular Formula	C10H8D3O4
Molecular Weight	199.22 g/mol (approx.)
Synonyms	Deutero-3,4,5-Trimethoxybenzaldehyde; 3,4,5-Trimethoxybenzaldehyde-d3; Benzaldehyde-D3, 3,4,5-trimethoxy-; (Trideuteromethyl) 3,4,5-trimethoxybenzoate precursor; Gallaldehyde-D3 trimethyl ether; TMB-aldehyde-D3; Deuterated Syringaldehyde methyl ether
EINECS	Contact for details

Quality Control

Every batch of 3,4,5-Trimethoxybenzaldehyde-D3 is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including NMR (1H, 13C) and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment (D-atom %), and confirming the absence of significant impurities. Our quality systems support development and production for global markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (argon or nitrogen). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0% (by MS)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.