Description

2-Aminoethane-D4-Thiol Hcl is a deuterium-labeled derivative of cysteamine hydrochloride, where four hydrogen atoms are replaced by deuterium, serving as a stable isotope-labeled internal standard. This high-purity compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and metabolomics sectors for precise biomarker quantification, drug metabolism studies, and proteomic research.

Application

• Mass Spectrometry Internal Standard: Essential for accurate quantification in LC-MS/MS and GC-MS analyses, correcting for instrument variability and sample preparation losses.
• Pharmaceutical Research & Development: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track the metabolism and distribution of drug candidates containing thiol or amino groups.
• Biomarker Analysis: Enables precise measurement of endogenous thiols like cysteamine and cysteine in clinical and preclinical studies for disease research.
• Proteomics and Metabolomics: Serves as a stable isotope tag or reference compound in workflows analyzing protein modifications and metabolic pathways.
• Quality Control & Method Validation: Employed in analytical laboratories to validate and calibrate methods for purity and potency testing of APIs and related substances.
• Chemical Synthesis Research: Acts as a labeled building block for synthesizing more complex deuterated molecules for mechanistic and tracer studies.

Basic Information

Product Name	2-Aminoethane-D4-Thiol Hcl
CAS No.	1219805-04-5
Molecular Formula	C2D4H3NS•HCl
Molecular Weight	117.62 g/mol (for C2D4H3NS•HCl)
Synonyms	Cysteamine-d4 Hydrochloride; 2-Aminoethanethiol-d4 Hydrochloride; 2-Mercaptoethylamine-d4 Hydrochloride; β-Mercaptoethylamine-d4 Hydrochloride; Decarboxycysteine-d4 Hydrochloride; Aminoethyl Mercaptan-d4 Hydrochloride; Thioethanolamine-d4 Hydrochloride; (2-Deuteroamino-1,1,2,2-tetradeuteroethyl)thiol Hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Aminoethane-D4-Thiol Hcl is manufactured under strict quality systems to ensure the high isotopic purity and chemical integrity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-content), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to cGMP principles for research-grade materials, ensuring traceability, consistency, and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a desiccator to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.