Description

1-Bromo-3-Chloro-5-Fluorobenzene-D3 is a deuterated aromatic building block of significant importance in advanced chemical synthesis and analytical research. This compound is specifically valued for its role as a stable isotope-labeled internal standard, enabling precise quantification and metabolic pathway tracing in mass spectrometry. It is primarily required by pharmaceutical R&D laboratories, agrochemical developers, and contract research organizations (CROs) engaged in the development of novel active ingredients and sophisticated analytical methods.

Application

• Pharmaceutical Research & Development: Serves as a critical deuterium-labeled intermediate or internal standard in the synthesis and bioanalytical studies of new drug candidates, particularly for pharmacokinetic (PK) and metabolism (ADME) investigations.
• Agrochemical Science: Used in the development and environmental fate studies of new pesticides and herbicides, where isotopic labeling is essential for tracking degradation pathways and residue analysis.
• Analytical Chemistry: Employed as a high-purity internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of its non-deuterated analogue in complex matrices.
• Material Science: Acts as a specialized monomer or precursor for synthesizing deuterated polymers or organic electronic materials, where isotopic substitution can modify physical properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations that require reliable, high-quality labeled compounds to support client projects in drug discovery and chemical analysis.

Basic Information

Product Name	1-Bromo-3-Chloro-5-Fluorobenzene-D3
CAS No.	1219805-00-1
Molecular Formula	C6H2D3BrClF
Molecular Weight	213.46 g/mol (deuterated)
Synonyms	3-Bromo-5-Chloro-1-Fluorobenzene-D3; 5-Bromo-3-Chloro-1-Fluorobenzene-D3; 1-Fluoro-3-bromo-5-chlorobenzene-D3; Benzene-D3, 1-bromo-3-chloro-5-fluoro-; (2,4,6-Trideuterio)-1-bromo-3-chloro-5-fluorobenzene; BCFB-D3; Deuterated BCFB; Bromochlorodifluorobenzene-D3 (isomer specific)
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-3-Chloro-5-Fluorobenzene-D3 is produced and analyzed under strict quality management protocols. We ensure high chemical purity and isotopic enrichment, typically exceeding 98% (chemical) and 99% atom D, to meet the stringent requirements of research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment (by 1H NMR or MS), and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.