Description

β-Hydroxybutyric Acid-D4 Sodium Salt CAS NO 1219804-68-8 is a stable isotope-labeled sodium salt of β-hydroxybutyrate, where four hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring precise and accurate analytical measurements. It is a critical reagent for researchers and quality control laboratories in pharmaceutical development, clinical diagnostics, and metabolic research focusing on ketosis and energy metabolism.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a crucial internal standard for the accurate quantification of endogenous β-hydroxybutyric acid in biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in pharmacokinetic and metabolic stability studies of drug candidates targeting metabolic pathways, diabetes, or ketogenic states.
• Clinical Diagnostics: Enables the development and validation of high-precision clinical assays for monitoring diabetic ketoacidosis (DKA) and nutritional ketosis.
• Nutritional & Sports Science Research: Facilitates precise measurement of ketone body levels in studies investigating ketogenic diets, fasting, and exercise physiology.
• Metabolomics & Biomarker Discovery: A key standard in targeted metabolomics panels for investigating disorders of fatty acid oxidation and energy metabolism.
• Quality Control & Reference Standards: Employed by manufacturers of in-vitro diagnostic (IVD) kits and clinical chemistry reagents to ensure assay accuracy and reliability.

Basic Information

Product Name	β-Hydroxybutyric Acid-D4 Sodium Salt
CAS No.	1219804-68-8
Molecular Formula	C4H3D4NaO3
Molecular Weight	130.11 g/mol (for C4H3D4NaO3)
Synonyms	Sodium 3-Hydroxybutyrate-D4; Sodium β-Hydroxybutyrate-D4; 3-Hydroxybutyric Acid-d4 Sodium Salt; BHB-d4 Sodium Salt; (R,S)-3-Hydroxybutyric Acid-d4 Sodium Salt; 3-Hydroxybutanoic-3,4,4,4-d4 Acid Sodium Salt; Ketone Body-d4 Sodium Salt; DL-3-Hydroxybutyric Acid-d4 Sodium Salt
EINECS	Contact for details

Quality Control

Our β-Hydroxybutyric Acid-D4 Sodium Salt is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to ensure high chemical and isotopic purity suitable for sensitive analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results is provided with every shipment to guarantee traceability and compliance with your research or quality specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by NMR/HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.