Description

2,4-Difluorobenzoic-D3 Acid is a deuterium-labeled isotopologue of 2,4-difluorobenzoic acid, a key building block in advanced chemical synthesis. This high-purity, isotopically enriched compound is essential for creating internal standards used in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical measurements. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and analytical reference material industries for drug metabolism studies, pharmacokinetics, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the precise quantification of 2,4-difluorobenzoic acid and related metabolites in complex biological matrices like plasma and urine.
• Pharmaceutical Research & Development: Used in drug discovery and development for conducting Absorption, Distribution, Metabolism, and Excretion (ADME) studies and stable isotope labeling experiments.
• Metabolite Identification & Tracking: Enables accurate tracking and identification of drug metabolites in preclinical and clinical studies due to its distinct mass shift.
• Agrochemical Analysis: Employed in environmental and residue analysis for fluorinated pesticides and herbicides, improving detection reliability.
• Synthesis of Labeled Compounds: Acts as a deuterated synthon for the preparation of more complex isotopically labeled target molecules for research.
• Quality Control & Method Validation: Essential for developing and validating robust analytical methods in GLP/GMP-compliant laboratories.

Basic Information

Product Name	2,4-Difluorobenzoic-D3 Acid
CAS No.	1219804-63-3
Molecular Formula	C7H2D3F2O2
Molecular Weight	159.13 g/mol (approx.)
Synonyms	2,4-Difluorobenzoic-3,5,6-d3 Acid; Benzoic-3,5,6-d3 Acid, 2,4-difluoro-; Deuterated 2,4-DFBA; [2H3]-2,4-Difluorobenzoic Acid; 2,4-Difluorobenzoic Acid (phenyl-d3); 2,4-DFBA-d3; 1219804-63-3 (CAS); 2,4-Difluorobenzoic Acid-d3
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluorobenzoic-D3 Acid is manufactured and analyzed under strict quality protocols to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing, including NMR and mass spectrometry for isotopic enrichment verification and HPLC for chemical purity, to ensure compliance with research and analytical standards. Certificates of Analysis (COA) detailing batch-specific data for identity, purity (HPLC), isotopic purity (NMR/MS), and water content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Isotopic Purity (NMR/MS)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.