Description

4-Morpholine-D8-Carbonyl Chloride is a deuterated derivative of morpholine-4-carbonyl chloride, where eight hydrogen atoms are replaced with deuterium, serving as a stable isotope-labeled compound. This high isotopic purity is critical for applications requiring minimal background interference and maximum signal clarity in analytical techniques. It is an essential building block and analytical standard for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise metabolic and degradation pathway studies.

Application

• Pharmaceutical Research & Development: Used as a deuterated synthetic intermediate or internal standard in the development of new drug candidates, particularly for pharmacokinetic (PK) and metabolism studies via LC-MS.
• Analytical Chemistry & Metabolomics: Serves as a critical standard in quantitative mass spectrometry for the accurate detection and measurement of morpholine-containing compounds in complex biological matrices.
• Agrochemical Development: Employed in the synthesis and analysis of deuterated agrochemicals to study environmental fate, degradation pathways, and residue analysis.
• Material Science: Acts as a precursor for introducing deuterated morpholine moieties into polymers or specialty chemicals to alter physical properties or create labeled materials for study.
• Contract Research Organizations (CROs): A vital reagent for CROs providing isotope-labeled standard synthesis and analytical testing services to global clients.

Basic Information

Product Name	4-Morpholine-D8-Carbonyl Chloride
CAS No.	1219804-24-6
Molecular Formula	C5D8ClNO2
Molecular Weight	169.64 g/mol (for D8 isotopologue)
Synonyms	Morpholine-4-carbonyl-D8 chloride; Perdeuteromorpholine-4-carbonyl chloride; Tetradeutero-2H-1,4-oxazinane-4-carbonyl chloride; 4-Carboxy-D8-morpholine chloride; Deuterated Morpholine Carbonyl Chloride; D8-Morpholine-4-Carbonyl Chloride; 2,2,3,3,5,5,6,6-Octadeuteromorpholine-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Morpholine-D8-Carbonyl Chloride is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including assay (by NMR or titration), isotopic enrichment (by MS), and identification (by IR/NMR). A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0%
Isotopic Purity (D8, by MS)	≥ 98 atom % D
Chemical Purity (by GC/HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.