Description

2,6-Difluorobenzoic-D3 Acid is a deuterium-labeled isotopologue of 2,6-difluorobenzoic acid, where three hydrogen atoms are replaced by deuterium (CAS NO 1219804-21-3). This high-purity stable isotope-labeled compound is essential for creating reliable internal standards in quantitative mass spectrometry, ensuring unparalleled accuracy and reproducibility in analytical workflows. It is a critical material for researchers and quality control laboratories in the pharmaceutical, agrochemical, and environmental testing sectors who require precise quantification of metabolites, impurities, or active ingredients.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for pharmacokinetic and bioanalytical studies.
• Metabolite Tracing & Drug Metabolism Studies: Enables precise tracking and quantification of drug metabolites and degradation pathways in vivo and in vitro.
• Pharmaceutical Impurity Profiling: Used in the development and validation of methods to accurately measure genotoxic impurities and related substances in active pharmaceutical ingredients (APIs).
• Environmental Analysis: Serves as a stable isotope-labeled surrogate standard for the detection and quantification of fluorinated benzoic acid derivatives in environmental samples.
• Agrochemical Research: Facilitates the analysis of pesticide residues and their environmental fate through precise isotopic dilution techniques.
• Synthetic Intermediate: Acts as a specialized building block for the synthesis of deuterium-labeled complex molecules for research and diagnostic purposes.

Basic Information

Product Name	2,6-Difluorobenzoic-D3 Acid
CAS No.	1219804-21-3
Molecular Formula	C7D3F2O2
Molecular Weight	161.11 g/mol
Synonyms	2,6-Difluorobenzoic-3,4,5-d3 Acid; Benzoic-3,4,5-d3 Acid, 2,6-difluoro-; Deuterated 2,6-Difluorobenzoic Acid; [2H3]-2,6-Difluorobenzoic Acid; 2,6-DFBA-d3; 2,6-Difluorobenzoic Acid (phenyl-d3); 2,6-Difluorobenzoic Acid-d3
EINECS	Contact for details

Quality Control

Our 2,6-Difluorobenzoic-D3 Acid is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing lot-specific results are provided and available upon request, supporting compliance with GLP and ISO 17025 standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.