Description

4-Fluorobenzyl-A,A-D2 Chloride is a deuterated benzyl chloride derivative, a high-value building block for the synthesis of isotopically labeled compounds. Its core value lies in enabling advanced research and development in medicinal chemistry and pharmacology by providing a stable deuterium label, which can significantly alter the metabolic profile and pharmacokinetics of target molecules. This compound is essential for pharmaceutical researchers, agrochemical developers, and contract research organizations (CROs) focused on creating next-generation deuterated active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: A critical precursor for incorporating deuterium into drug candidates to potentially improve metabolic stability, reduce toxicity, and extend patent life.
• Medicinal Chemistry & Drug Discovery: Used as a versatile alkylating agent in the research and development of novel therapeutic agents, particularly in neurological and oncological targets.
• Metabolic Pathway Tracing: Serves as a stable isotope-labeled intermediate in the synthesis of probes for studying drug metabolism and pharmacokinetics (DMPK) via mass spectrometry.
• Agrochemical Research: Employed in the development of novel, isotopically labeled pesticides and herbicides for environmental fate and metabolism studies.
• Material Science Intermediates: Can be utilized in the synthesis of specialized polymers or liquid crystals where the fluorine and deuterium atoms impart specific electronic or physical properties.
• Contract Manufacturing & Custom Synthesis: Supplied to CDMOs for the production of bespoke deuterated compounds under cGMP or research-grade conditions.

Basic Information

Product Name	4-Fluorobenzyl-A,A-D2 Chloride
CAS No.	1219804-18-8
Molecular Formula	C7H5D2ClF
Molecular Weight	146.59 g/mol
Synonyms	4-Fluorobenzyl-α,α-d2 Chloride; (4-Fluorophenyl)-d2-methyl Chloride; 1-(Chloromethyl-d2)-4-fluorobenzene; α,α-Dideutero-4-fluorobenzyl Chloride; 4-Fluoro-α,α-dideuterobenzyl Chloride; p-Fluorobenzyl-α,α-d2 Chloride; Deutero-labeled 4-Fluorobenzyl Chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Fluorobenzyl-A,A-D2 Chloride is produced and analyzed under strict quality protocols to ensure consistency and reliability for sensitive research applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with client specifications and industry standards. Certificates of Analysis (COA) detailing purity, isotopic enrichment (D-content), and impurity profiles are available upon request. We support development under quality systems suitable for non-GMP and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-content, NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.