Description

4-Fluorobenzyl-D6 Chloride is a deuterated derivative of 4-fluorobenzyl chloride, a versatile alkylating agent and key synthetic intermediate. This deuterium-labeled compound is specifically designed for use as an internal standard in quantitative mass spectrometry, ensuring superior accuracy and reliability in analytical methods. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors who require precise isotopic labeling for drug metabolism studies (DMPK), pharmacokinetics, and the development of novel chemical entities.

Application

• Primary use as an internal standard for the quantification of 4-fluorobenzyl chloride and related metabolites in LC-MS/MS and GC-MS analysis.
• Critical reagent in deuterium labeling for pharmaceutical research, particularly in Drug Metabolism and Pharmacokinetics (DMPK) studies.
• Synthetic intermediate for the preparation of deuterated analogs of pharmaceuticals, agrochemicals, and specialty materials.
• Used in mechanistic studies and reaction pathway elucidation via isotopic tracing.
• Application in the development and validation of regulatory-compliant analytical methods for bioanalysis.
• Building block for labeled ligands, catalysts, and other advanced research chemicals.

Basic Information

Product Name	4-Fluorobenzyl-D6 Chloride
CAS No.	1219804-13-3
Molecular Formula	C7D6ClF
Molecular Weight	159.62 g/mol
Synonyms	α,α,α,2,3,5,6-D7-4-Fluorobenzyl Chloride; (2,3,5,6-D4-4-Fluorophenyl)-D3-methyl Chloride; 1-(Chloromethyl)-2,3,5,6-tetradeuterio-4-fluoro-benzene-d3; 4-Fluoro-(α,α,α-d3)benzyl-d3 Chloride; Deutero-4-Fluorobenzyl Chloride; 4-Fluorobenzyl-d6 Chloride; Perdeuterated 4-Fluorobenzyl Chloride
EINECS	Contact for details

Quality Control

Our 4-Fluorobenzyl-D6 Chloride is produced under strict quality management systems to ensure high isotopic purity and chemical integrity, critical for its role as an analytical standard. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, MS, and HPLC. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-atom %), chemical purity, and identity confirmation is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0% (by MS)
Chemical Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.