Description

4-Fluorobenzyl--D4 Chloride is a deuterium-labeled isotopologue of 4-fluorobenzyl chloride, a valuable building block in synthetic organic chemistry. This compound is specifically designed for use in advanced research and development, particularly in the fields of pharmaceutical and agrochemical sciences where deuterium labeling is critical. It serves as a key intermediate for the synthesis of deuterated active pharmaceutical ingredients (APIs) and other labeled compounds for metabolic, pharmacokinetic, and mechanistic studies. Researchers and process chemists in pharmaceutical R&D, contract research organizations (CROs), and fine chemical manufacturers will find this material essential for their labeling programs.

Application

• Deuterated Pharmaceutical Intermediate: A critical precursor for synthesizing deuterium-labeled drug candidates and active pharmaceutical ingredients (APIs) to study drug metabolism and improve pharmacokinetic profiles.
• Metabolic Tracer Synthesis: Used in the preparation of internal standards and tracers for mass spectrometry-based analytical methods, including LC-MS and GC-MS, in bioanalytical and DMPK (Drug Metabolism and Pharmacokinetics) studies.
• Agrochemical Research: Employed in the development of novel, labeled agrochemicals to investigate environmental fate, degradation pathways, and residue analysis.
• Material Science Research: Acts as a building block for creating deuterated polymers, liquid crystals, or other advanced materials where isotopic labeling is used to probe structure and dynamics.
• NMR Spectroscopy: Serves as a starting material for synthesizing deuterated probes or solvents used in nuclear magnetic resonance (NMR) spectroscopy to simplify spectra and study molecular interactions.
• Chemical Biology & Proteomics: Useful for the synthesis of isotopically labeled probes, tags, or cross-linkers for protein labeling, structural biology, and proteomic research.

Basic Information

Product Name	4-Fluorobenzyl--D4 Chloride
CAS No.	1219804-10-0
Molecular Formula	C7H3D4ClF
Molecular Weight	158.61 g/mol (for deuterated form)
Synonyms	1-(Chloromethyl)-4-fluorobenzene-d4; (4-Fluorophenyl-d4)methyl chloride; alpha,alpha,alpha,α-D4-4-Fluorobenzyl Chloride; 4-Fluorobenzyl-d4 Chloride; p-Fluorobenzyl-d4 Chloride; Deutero-p-fluorobenzyl Chloride; Benzene-d4, 1-(chloromethyl)-4-fluoro-; 4-Fluorobenzyl Chloride-d4
EINECS	Contact for details

Quality Control

Our 4-Fluorobenzyl--D4 Chloride is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, suitable for sensitive research applications. Each batch is characterized by advanced analytical techniques including NMR (¹H, ¹³C, ¹⁹F), Mass Spectrometry (MS), and HPLC to confirm deuterium incorporation, chemical purity, and identity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D atom %), assay, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D atom %)	≥ 98.0% (by MS or NMR)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.