Description

2,2-Dimethylbutyric-D11 Acid is a deuterium-labeled isotopologue of 2,2-dimethylbutyric acid, where eleven hydrogen atoms are replaced by deuterium. This high isotopic purity is critical for applications requiring non-radioactive isotopic tracing and as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and eliminating matrix effects. It is an essential material for researchers and manufacturers in pharmaceutical development, metabolic studies, and analytical chemistry, where precise quantification and metabolic pathway elucidation are paramount.

Application

• Internal Standard for Mass Spectrometry (MS): Used in LC-MS and GC-MS for the accurate quantification of 2,2-dimethylbutyric acid and related compounds in complex biological and chemical matrices.
• Metabolic Pathway Tracing: Serves as a stable isotope-labeled tracer in pharmacokinetic, pharmacodynamic, and metabolic flux studies to track the fate of molecules in biological systems.
• Pharmaceutical Impurity Profiling & Reference Standard: Employed as a certified reference material (CRM) for method development, validation, and the identification of impurities or degradation products in Active Pharmaceutical Ingredients (APIs).
• NMR Spectroscopy Solvent & Reagent: Utilized as a deuterated reagent or in deuterated solvents for nuclear magnetic resonance (NMR) spectroscopy to avoid signal interference from protons.
• Organic Synthesis Intermediate: Acts as a building block for synthesizing more complex deuterium-labeled compounds for research and development.
• Environmental & Food Safety Analysis: Applied in advanced analytical methods for detecting and quantifying trace levels of contaminants or metabolites in environmental and food samples.

Basic Information

Product Name	2,2-Dimethylbutyric-D11 Acid
CAS No.	1219804-04-2
Molecular Formula	C6D11HO2
Molecular Weight	131.22 g/mol (for D11 isotopologue)
Synonyms	2,2-Dimethylbutyric-d11 Acid; Pivalic-d11 Acid Ethyl Ester Derivative; (D11)-2,2-Dimethylbutanoic Acid; Deuterated Trimethylacetic Acid Derivative; Hexanoic-3,3,4,4,4-d5,2,2-dimethyl-d6 Acid; 2,2-Dimethyl[2H11]butyric Acid; Isotopic Labeled 2,2-Dimethylbutyric Acid
EINECS	Contact for details

Quality Control

Every batch of 2,2-Dimethylbutyric-D11 Acid is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing including assay, isotopic enrichment (D-content) by NMR or MS, and identification. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with each shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.