Description

1-Bromo-2,4-Difluorobenzene-D3 is a deuterated aromatic compound, specifically a benzene derivative where three hydrogen atoms are replaced by deuterium, serving as a stable isotope-labeled building block. This deuteration is critical for applications requiring precise analytical tracking, minimizing metabolic interference in research, and enhancing the reliability of spectroscopic data. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for drug discovery, metabolic studies, and as a precursor in specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Acts as a key deuterated synthon in the development of novel Active Pharmaceutical Ingredients (APIs), particularly for drugs targeting the central nervous system and anti-infectives.
• Metabolic Research & Tracing: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for accurate quantification and metabolic pathway studies.
• Agrochemical Development: Employed in the synthesis of deuterated pesticides and herbicides to study environmental fate, degradation, and residue analysis.
• Material Science Precursor: Serves as a building block for creating deuterated liquid crystals, organic semiconductors, and polymers for specialized optical and electronic applications.
• NMR Spectroscopy Solvent & Reagent: Provides a spectroscopically silent background in Nuclear Magnetic Resonance (NMR) experiments, improving signal clarity for structural analysis.

Basic Information

Product Name	1-Bromo-2,4-Difluorobenzene-D3
CAS No.	1219803-87-8
Molecular Formula	C6H2D3BrF2
Molecular Weight	195.99 g/mol
Synonyms	2,4-Difluorobromobenzene-D3; 2,4-Difluoro-1-bromobenzene-D3; Benzene-D3, 1-bromo-2,4-difluoro-; (2,4-Difluorophenyl)-D3 bromide; Deutero-1-Bromo-2,4-difluorobenzene; 1-Bromo-2,4-difluoro(2,3,5-D3)benzene; 2,4-DFB-D3
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,4-Difluorobenzene-D3 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹⁹F) for structural confirmation and deuterium incorporation, GC or HPLC for chemical and isotopic purity assessment, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain isotopic purity and chemical stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (NMR)	Conforms to structure
Deuterium Content (Atom % D)	≥ 98.0%
Chemical Purity (GC/HPLC)	≥ 98.0%
Isotopic Purity (by MS)	≥ 98.0% (D3)
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.