Description

Cetirizine-D 4 is a high-purity, deuterated isotopologue of the widely used antihistamine cetirizine. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, providing superior accuracy and reliability in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering internal standard for the precise quantification of cetirizine in biological matrices (plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug concentration over time, critical for determining absorption, distribution, metabolism, and excretion (ADME) profiles.
• Bioequivalence & Bioavailability Testing: Supports rigorous analytical protocols required for generic drug approval and formulation development.
• Metabolite Identification & Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex samples.
• Forensic & Clinical Toxicology: Used in confirmatory testing for cetirizine presence and concentration in forensic or therapeutic drug monitoring contexts.
• Method Development & Validation: Serves as a critical component in developing, optimizing, and validating robust, regulatory-compliant analytical methods (e.g., following FDA/EMA guidelines).

Basic Information

Product Name	Cetirizine-D 4
CAS No.	1219803-84-5
Molecular Formula	C21H21D4ClN2O3
Molecular Weight	388.90 g/mol (deuterated form)
Synonyms	Cetirizine-d4; [²H₄]-Cetirizine; Deutetrated Cetirizine (D4); 2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid-d4; (RS)-[²H₄]-Cetirizine; Zyrtec-d4; Internal Standard for Cetirizine
EINECS	Contact for details

Quality Control

Our Cetirizine-D 4 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and confirming structural identity. We support compliance with cGMP and ISO 9001 standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms to structure
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.